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Invitrogen™ FPGS Recombinant Rabbit Monoclonal Antibody (30C11)
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Catalog No. FEMA550184
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100 μL
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FEMA550184 100 μL
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Catalog No. FEMA550184 Supplier Invitrogen™ Supplier No. MA550184
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Description

Rabbit Recombinant Monoclonal Antibody

FPGS Recombinant Monoclonal Antibody for Flow, ELISA

Folylpoly-gamma-glutamate synthetase (FPGS) catalyzes the addition of several equivalents of glutamic acid to the gamma-carboxyl group in the side chain of folate cofactors and analogs. Folylpoly-gamma-glutamate synthetase has three functions in folate homeostasis in mammals: polyglutamation prevents efflux of folate cofactors from the cell, it increases the binding of folate cofactors to some of the enzymes of folate interconversion and biosynthesis, and it appears to allow the accumulation of folates in the mitochondria that are required for glycine synthesis. Folylpoly-gamma-glutamate synthetase is widely expressed in human tumors and is tightly linked either to proliferation or to a lack of differentiation. The cytotoxicity of both thymidylate synthase and purine inhibitors requires continued inhibition of target for greater than one generation time, so that the integrative function of FPGS adds considerably to the efficiency of folate antimetabolites.
TRUSTED_SUSTAINABILITY

Specifications

Antigen FPGS
Applications ELISA, Flow Cytometry
Classification Recombinant Monoclonal
Clone 30C11
Concentration 0.4 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene FPGS
Gene Accession No. Q05932
Gene Alias AA408187; folylpoly-gamma-glutamate synthetase; folylpolyglutamate synthase; folylpolyglutamate synthase, mitochondrial; folylpolyglutamyl synthetase; FPGS; Tetrahydrofolate synthase; tetrahydrofolylpolyglutamate synthase
Gene Symbols FPGS
Host Species Rabbit
Immunogen A synthesized peptide derived from Human FPGS.
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 2356
Target Species Human
Content And Storage -20°C or -80°C if preferred
Product Type Antibody
Form Liquid
Isotype IgG
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