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Invitrogen™ FPR1 Polyclonal Antibody
Rabbit Polyclonal Antibody
Supplier: Invitrogen™ PA533534
Description
Percent identity with other species by BLAST analysis: Human, Chimpanzee, Monkey (100%) Gorilla (94%) Orangutan (88%).
FPR1 is a member of chemoattractant/chemokine GPCRs expressed mainly on leukocytes, neutrophils and monocytes. FPR1 is a seven transmembrane pertussis toxin-sensitive GPCR and binds to formylated peptides generated by bacteria resulting in leukocyte trafficking to the site of inflammation. Ligand binding to FPR results in activation of multiple effectors including phospholipase C leading to calcium mobilization and PKC activation. Other implications of FPR signaling include polarization of actin cytoskeleton, activation of various integrins, increased cell migration, phagocytosis, degranulation and release of reactive oxygen intermediates.
Specifications
FPR1 | |
Polyclonal | |
Unconjugated | |
FPR1 | |
fMet-Leu-Phe receptor; fMLF-R; FMLP; fMLP receptor; formyl peptide receptor 1; FPR; Fpr receptor; FPR1; FPR-1; lipoxin A4 receptor; LXA4R; N-formyl peptide receptor; N-formylpeptide chemoattractant receptor | |
Rabbit | |
Antigen affinity chromatography | |
RUO | |
2357 | |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
Liquid |
Immunohistochemistry (Paraffin) | |
1 mg/mL | |
PBS with 0.1% sodium azide | |
P21462 | |
FPR1 | |
Synthetic 16 amino acid peptide from 3rd extracellular domain of human FPR1. | |
50 μg | |
Primary | |
Human, Monkey | |
Antibody | |
IgG |
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