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Invitrogen™ FPR3 Polyclonal Antibody
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Catalog No. PIPA533540
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50 μg
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PIPA533540 50 μg
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Catalog No. PIPA533540 Supplier Invitrogen™ Supplier No. PA533540
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Description

Rabbit Polyclonal Antibody

Percent identity with other species by BLAST analysis: Human, Chimpanzee, Gorilla, Orangutan, Monkey (100%) Gibbon (94%).

The N-formyl peptide receptor (FPR) family is comprised of three members, FPR, FPR3 (also designated FPRL1, lipoxin A4 receptor, FPRH1 or FPR2) and FPR like-2 (FPRL2), all of which are chemotactic G protein-coupled receptors that contain seven transmembrane domains. These receptors are found on the surface of phagocytic leukocytes, such as neutrophils and monocytes, and each family member contains specific residues, which are responsible for determining its ligand specificity. FPR3 is a promiscuous receptor that binds to several ligands, including lipoxin A4, N-formyl-methionyl-leucyl-phenylalanine (fMLP), serum amyloid A (SAA), prion peptide and the 42 amino acid form of beta amyloid. Upon activation, FPR3 induces migration and calcium mobilization in human monocytes and neutrophils and is involved in inflammatory and host defense responses. FPR3 may mediate inflammation in prion and Alzheimer's diseases, which makes it a potential target for therapeutic agents.
TRUSTED_SUSTAINABILITY

Specifications

Antigen FPR3
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.1% sodium azide
Gene FPR3
Gene Accession No. P25089
Gene Alias ALX; FML2_HUMAN; FMLP-related receptor I; FMLP-related receptor II; FMLP-R-I; FMLP-R-II; FMLPY; formyl peptide receptor 3; Formyl peptide receptor related sequence 1; Formyl peptide receptor-like 1; formyl peptide receptor-like 2; Formyl peptide receptor-related sequence 1; Fpr2; FPR3; FPRH1; FPRH2; Fprl1; FPRL2; Fpr-rs1; Fpr-s1; Lipoxin A4 receptor; LXA4 receptor; Lxa4r; LXA4-R; N-formyl peptide receptor 2; N-formyl peptide receptor 3; N-formylpeptide receptor-like 1; RGD1566044; RMLP-R-I
Gene Symbols FPR3
Host Species Rabbit
Immunogen Synthetic 18 amino acid peptide from 2nd transmembrane domain of human FPR3 / FPRH2.
Purification Method Antigen affinity chromatography
Quantity 50 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 2359
Target Species Human, Monkey
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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