FPR3 Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific PA575750

Catalog No. PIPA575750

Description

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

The N-formyl peptide receptor (FPR) family is comprised of three members, FPR, FPR3 (also designated FPRL1, lipoxin A4 receptor, FPRH1 or FPR2) and FPR like-2 (FPRL2), all of which are chemotactic G protein-coupled receptors that contain seven transmembrane domains. These receptors are found on the surface of phagocytic leukocytes, such as neutrophils and monocytes, and each family member contains specific residues, which are responsible for determining its ligand specificity. FPR3 is a promiscuous receptor that binds to several ligands, including lipoxin A4, N-formyl-methionyl-leucyl-phenylalanine (fMLP), serum amyloid A (SAA), prion peptide and the 42 amino acid form of beta amyloid. Upon activation, FPR3 induces migration and calcium mobilization in human monocytes and neutrophils and is involved in inflammatory and host defense responses. FPR3 may mediate inflammation in prion and Alzheimer's diseases, which makes it a potential target for therapeutic agents.

Specifications

• Antigen: FPR3
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: FPR3
• Gene Alias: ALX; FML2_HUMAN; FMLP-related receptor I; FMLP-related receptor II; FMLP-R-I; FMLP-R-II; FMLPY; formyl peptide receptor 3; Formyl peptide receptor related sequence 1; Formyl peptide receptor-like 1; formyl peptide receptor-like 2; Formyl peptide receptor-related sequence 1; Fpr2; FPR3; FPRH1; FPRH2; Fprl1; FPRL2; Fpr-rs1; Fpr-s1; Lipoxin A4 receptor; LXA4 receptor; Lxa4r; LXA4-R; N-formyl peptide receptor 2; N-formyl peptide receptor 3; N-formylpeptide receptor-like 1; RGD1566044; RMLP-R-I
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 14294, 2359, 292413
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: O08790, P25089
• Gene Symbols: FPR3
• Immunogen: Synthetic peptide corresponding to residues in Human FPR3
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG