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  5. Tocris Bioscience™ FRAX 486

Tocris Bioscience™ FRAX 486
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Catalog No. 519010 Shop All R&D Systems Products
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Catalog No. Quantity
51-901-0 10 mg
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Catalog No. 51-901-0 Supplier Tocris Bioscience™ Supplier No. 5190/10
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Description

Potent PAK inhibitor; brain penetrant and orally bioavailable

FRAX 486 is a potent p21-activated kinase (PAK) inhibitor (IC50 values are 14, 33, 39 and 575 nM for PAK1, PAK2, PAK3 and PAK4 respectively). Blocks and reverses the DISC1 knockdown-induced reduction in dendritic spine size in cortical neurons. Attenuates dendritic spine elimination and enhances spine generation in DISC1 knockdown mice. Ameliorates autism-like behavioral symptoms in fragile X mental retardation 1 (Fmr1) knockout mice. Brain penetrant and orally bioavailable.

Specifications

Quantity 10 mg
Product Type FRAX 486
Purity >98%
Molecular Weight (g/mol) 513.39
Inhibitors FRAX 486

For Research Use Only

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