Tocris Bioscience™ FRAX 597

Catalog No.	Quantity
60-291-0	10 mg
60-295-0	50 mg

Catalog No. 60-291-0

Supplier: Tocris Bioscience™ 6029/10

Description

Potent group I PAK inhibitor

FRAX 597 is a potent group I PAK inhibitor (IC50 values are 8, 13 and 19 nM for PAK1, 2 and 3, respectively). FRAX 597 exhibits significant inhibition of YES1, RET, CSF1R and TEK at 100 nM, but is inactive against group II PAK isoforms (IC50 >10 μM for PAK4). FRAX 597 inhibits proliferation of pancreatic cancer and schwannoma cells in vitro and exhibits antitumor effects in mice.

Specifications

• Chemical Name or Material: FRAX 597
• CAS: 1286739-19-2
• Synonym: 6-[2-Chloro-4-(5-thiazolyl)phenyl]-8-ethyl-2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]pyrido[2,3-d]pyrimidin-7-(8H)-one
• Quantity: 10 mg
• Solubility: Soluble to 20mM in DMSO
• Target: PAK Inhibitors
• Molecular Formula: C₂₉H₂₈ClN₇OS
• Formula Weight: 558.1
• Physical Form: Solid
• Color: Yellow
• Product Type: Bioactive Small Molecule
• Purity: >98%

For Research Use Only.