Invitrogen™ FRMPD1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA560166

Catalog No. PIPA560166

Description

Immunogen sequence: RRGGVKKYAK TLRKRRSFLQ TDYTSQVSFP LVPSASLESV DDVCYYDREP YLALGAPSPT VSSLQDMQGE PGLLETKALG LLAPLRETKS TNPASRVMEM EPET Highest antigen sequence identity to the following orthologs: Mouse - 88%, Rat - 85%.

The FERM and PDZ domain containing (FRMPD) protein family consists of four proteins that contain a FERM (Four-point-one, erzin, radixin, moesin) domain and at least one PDZ (PSD-95/Discs large/Zonula-occuldens-1) domain. FRMPD1 was initially identified through a yeast two-hybrid screening with Activator of G-protein signaling 3 (AGS3), a protein that acts to stabilize the GDP-bound conformation of Gai, as the bait. FRMPD1 binds to the tetratricopeptide repeat of AGS3 and stabilizes AGS3 in a membrane environment. Suppression of FRMPD1 in Cath.a-differentiated neuronal cells decreased the level of endogenous AGS3 in membrane fractions by ~50% and enhanced the inhibition of forskolin-induced increases in cAMP. Co-immunoprecipitation studies indicate that the interaction of AGS3 with FRMPD1 is mutually exclusive with the interaction of AGS3 with Gai3, suggesting that FRMPD1 may position AGS3 in the membrane where it can then interact with Galphai.

Specifications

• Antigen: FRMPD1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: FRMPD1
• Gene Alias: BC031840; FERM and PDZ domain containing 1; FERM and PDZ domain-containing protein 1; FERM domain-containing protein 2; FRMD2; Frmpd1; Kiaa0967; mKIAA0967; RP11-263I4.1
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 22844
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 0.1 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q5SYB0
• Gene Symbols: FRMPD1
• Immunogen: Recombinant protein corresponding to Human FRMPD1. Recombinant protein control fragment (Product #RP-92882).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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