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Invitrogen™ FRMPD1 Polyclonal Antibody
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Catalog No. PIPA560166
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100 μL
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PIPA560166 100 μL
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Catalog No. PIPA560166 Supplier Invitrogen™ Supplier No. PA560166
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: RRGGVKKYAK TLRKRRSFLQ TDYTSQVSFP LVPSASLESV DDVCYYDREP YLALGAPSPT VSSLQDMQGE PGLLETKALG LLAPLRETKS TNPASRVMEM EPET Highest antigen sequence identity to the following orthologs: Mouse - 88%, Rat - 85%.

The FERM and PDZ domain containing (FRMPD) protein family consists of four proteins that contain a FERM (Four-point-one, erzin, radixin, moesin) domain and at least one PDZ (PSD-95/Discs large/Zonula-occuldens-1) domain. FRMPD1 was initially identified through a yeast two-hybrid screening with Activator of G-protein signaling 3 (AGS3), a protein that acts to stabilize the GDP-bound conformation of Gai, as the bait. FRMPD1 binds to the tetratricopeptide repeat of AGS3 and stabilizes AGS3 in a membrane environment. Suppression of FRMPD1 in Cath.a-differentiated neuronal cells decreased the level of endogenous AGS3 in membrane fractions by ~50% and enhanced the inhibition of forskolin-induced increases in cAMP. Co-immunoprecipitation studies indicate that the interaction of AGS3 with FRMPD1 is mutually exclusive with the interaction of AGS3 with Gai3, suggesting that FRMPD1 may position AGS3 in the membrane where it can then interact with Galphai.
TRUSTED_SUSTAINABILITY

Specifications

Antigen FRMPD1
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 0.1 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene FRMPD1
Gene Accession No. Q5SYB0
Gene Alias BC031840; FERM and PDZ domain containing 1; FERM and PDZ domain-containing protein 1; FERM domain-containing protein 2; FRMD2; Frmpd1; Kiaa0967; mKIAA0967; RP11-263I4.1
Gene Symbols FRMPD1
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human FRMPD1. Recombinant protein control fragment (Product #RP-92882).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 22844
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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