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Invitrogen™ FRMPD1 Polyclonal Antibody
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Catalog No. PIPA520832
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100 μg
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Catalog No. Quantity
PIPA520832 100 μg
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Catalog No. PIPA520832 Supplier Invitrogen™ Supplier No. PA520832
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Description

Rabbit Polyclonal Antibody

A suggested positive control is K562 cell lysate. PA5-20832 can be used with blocking peptide PEP-0946.

The FERM and PDZ domain containing (FRMPD) protein family consists of four proteins that contain a FERM (Four-point-one, erzin, radixin, moesin) domain and at least one PDZ (PSD-95/Discs large/Zonula-occuldens-1) domain. FRMPD1 was initially identified through a yeast two-hybrid screening with Activator of G-protein signaling 3 (AGS3), a protein that acts to stabilize the GDP-bound conformation of Gai, as the bait. FRMPD1 binds to the tetratricopeptide repeat of AGS3 and stabilizes AGS3 in a membrane environment. Suppression of FRMPD1 in Cath.a-differentiated neuronal cells decreased the level of endogenous AGS3 in membrane fractions by ~50% and enhanced the inhibition of forskolin-induced increases in cAMP. Co-immunoprecipitation studies indicate that the interaction of AGS3 with FRMPD1 is mutually exclusive with the interaction of AGS3 with Gai3, suggesting that FRMPD1 may position AGS3 in the membrane where it can then interact with Galphai.
TRUSTED_SUSTAINABILITY

Specifications

Antigen FRMPD1
Applications Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene FRMPD1
Gene Accession No. Q5SYB0
Gene Alias BC031840; FERM and PDZ domain containing 1; FERM and PDZ domain-containing protein 1; FERM domain-containing protein 2; FRMD2; Frmpd1; Kiaa0967; mKIAA0967; RP11-263I4.1
Gene Symbols FRMPD1
Host Species Rabbit
Immunogen A 15 amino acid peptide from near the carboxy terminus of human FRMPD1.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 22844
Target Species Human
Content And Storage Maintain refrigerated at 2°C to 8°C for up to 3 months. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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