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Invitrogen™ FRS3 Polyclonal Antibody
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Catalog No. PIPA556385
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100 μL
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PIPA556385 100 μL
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Catalog No. PIPA556385 Supplier Invitrogen™ Supplier No. PA556385
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: GAGWRLSPEE PGWNGLAHRR AALLHYENLP PLPPVWESQA QQLGGEAGDD GDSRDGLTPS SNGFPDGEED ETPLQKPTST RAAIRSHGSF PVPLT Highest antigen sequence identity to the following orthologs: Mouse - 92%, Rat - 93%.

FRS3 (fibroblast growth factor receptor substrate 3), also known as FRS2B (FRS2-beta), is a 492 amino acid lipid-anchor adapter protein that contains one IRS-type PTB domain. Colocalizing to neural tissues with Tuj1, FRS3 functions as a feedback inhibitor of EGFR family members by preventing heterodimer formation between EGFR and ErbB2, thereby acting as a potential tumor suppressor. FRS3 is phosphorylated upon stimulation by FGF-2 or NGF and, acting as an adapter protein, links c-Fgr and NGF receptors to downstream signaling pathways. Interfering with the phosphorylation and nuclear translocation of ERK-2, FRS3 down-regulates ERK-2 expression. FRS3 likely interacts directly with GRB2, SH-PTP2, Flg, and Trk A, and may be involved in MAP kinase activation.
TRUSTED_SUSTAINABILITY

Specifications

Antigen FRS3
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.7 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene FRS3
Gene Accession No. O43559, Q52RG8
Gene Alias 4930417B13Rik; AI449674; FGFR substrate 3; FGFR-signaling adaptor SNT2; Fibroblast growth factor receptor substrate 3; FRS2B; Frs2beta; FRS2-beta; FRS3; Snt2; SNT-2; Suc1-associated neurotrophic factor target 2; suc1-associated neurotrophic factor target 2 (FGFR signalling adaptor); testicular tissue protein Li 71
Gene Symbols FRS3
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human FRS3. Recombinant protein control fragment (Product #RP-94865).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 10817, 316213
Target Species Human, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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