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Invitrogen™ FSHR Polyclonal Antibody
Rabbit Polyclonal Antibody
Supplier: Invitrogen™ PA550963
Description
FSH Receptor / FSHR Polyclonal Antibody detects endogenous levels of FSH Receptor / FSHR protein.
Follicle-Stimulating Hormone Receptor (FSHR) expression has been reported in ovary, uterus, and testis. ESTs have been isolated from testis libraries. G-protein Coupled Receptors (GPCRs) comprise one of the largest families of signaling molecules with more than a thousand members currently predicted to exist. All GPCRs share a structural motif consisting of seven membrane-spanning helices, and exist in both active and inactive forms. An array of activating ligands participate in the conformation of GPCRs which leads to signaling via G-proteins and downstream effectors. Ongoing studies have also shown the vast series of reactions which participate in the negative regulation of GPCRs. This turn-off activity has tremendous implications for the physiological action of the cell, and continues to drive pharmacological research for new drug candidates. Two blockbuster drugs which have been developed as GPCR-targeted pharmaceuticals are Zyprexa (Eli Lilly) and Claritin (Schering-Plough) which have multi-billion dollar shares of the mental health and allergy markets, respectively.
Specifications
FSHR | |
Polyclonal | |
Unconjugated | |
FSHR | |
follicle stimulating hormone receptor; follicle-stimulating hormone receptor; Follitropin receptor; FSH receptor; Fshr; FSH-R; FSHR1; FSHRO; LGR1; ODG1 | |
Rabbit | |
Antigen affinity chromatography | |
RUO | |
14309, 2492, 25449 | |
-20°C, Avoid Freeze/Thaw Cycles | |
Liquid |
ELISA, Immunohistochemistry, Western Blot, Immunocytochemistry | |
1 mg/mL | |
PBS with 0.5% BSA, 50% glycerol and 0.02% sodium azide; pH 7.4 | |
P20395, P23945, P35378 | |
FSHR | |
Synthesized peptide derived from the Internal region of human FSHR. | |
100 μL | |
Primary | |
Human, Mouse, Rat | |
Antibody | |
IgG |
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