Invitrogen™ FSHR Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA591952

Catalog No. PIPA591952

Description

Positive Samples: SW620; Cellular Location: Cell membrane, Multi-pass membrane protein Immunogen sequence: KNFRRDFFIL LSKCGCYEMQ AQIYRTETSS TVHNTHPRNG HCSSAPRVTS GSTYILVPLS HLAQN.

Follicle-Stimulating Hormone Receptor (FSHR) expression has been reported in ovary, uterus, and testis. ESTs have been isolated from testis libraries. G-protein Coupled Receptors (GPCRs) comprise one of the largest families of signaling molecules with more than a thousand members currently predicted to exist. All GPCRs share a structural motif consisting of seven membrane-spanning helices, and exist in both active and inactive forms. An array of activating ligands participate in the conformation of GPCRs which leads to signaling via G-proteins and downstream effectors. Ongoing studies have also shown the vast series of reactions which participate in the negative regulation of GPCRs. This turn-off activity has tremendous implications for the physiological action of the cell, and continues to drive pharmacological research for new drug candidates. Two blockbuster drugs which have been developed as GPCR-targeted pharmaceuticals are Zyprexa (Eli Lilly) and Claritin (Schering-Plough) which have multi-billion dollar shares of the mental health and allergy markets, respectively.

Specifications

• Antigen: FSHR
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: FSHR
• Gene Alias: follicle stimulating hormone receptor; follicle-stimulating hormone receptor; Follitropin receptor; FSH receptor; Fshr; FSH-R; FSHR1; FSHRO; LGR1; ODG1
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 14309, 2492, 25449
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot, Western Blot
• Concentration: 2.39 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: P20395, P23945, P35378
• Gene Symbols: FSHR
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 631-695 of human FSHR (NP_0001362).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG