Invitrogen™ FSTL3 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5121980

Catalog No. PIPA5121980

Description

FSTL3 Polyclonal Antibody for Western Blot, ICC/IF, IHC (P)

Follistatin-like 3 (FSTL3) is a gene located on chromosome 19p13.3 and encodes a secreted glycoprotein that belongs to the follistatin-related protein family. FSTL3 functions as an antagonist to members of the transforming growth factor-beta (TGF-β) superfamily, particularly inhibiting activin and myostatin signaling. This inhibitory action is crucial for regulating muscle growth, fertility, and inflammation. FSTL3 is expressed in various tissues, including the placenta, gonads, and skeletal muscle, where it modulates physiological processes by binding to and neutralizing the activities of its target ligands. Dysregulation of FSTL3 has been implicated in conditions such as muscle wasting, metabolic syndrome, and reproductive disorders, reflecting its role in maintaining tissue homeostasis and function. Research into FSTL3 focuses on its potential therapeutic applications in diseases involving TGF-β pathway dysregulation, offering insights into strategies for modulating growth factor activities in clinical settings.

Specifications

• Antigen: FSTL3
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: FSTL3
• Gene Alias: E030038F23Rik; FLRG; FLRGFSRP; follistatin like 3; follistatin-like 3; follistatin-like 3 (secreted glycoprotein); follistatin-like protein 3; Follistatin-related gene protein; follistatin-related protein 3; FSRP; FSTL3; UNQ674/PRO1308
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography, Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 83554
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 0.5 mg/mL
• Formulation: PBS with 50% glycerol and 0.05% ProClin 300; pH 7.4
• Gene Accession No.: Q9EQC7
• Gene Symbols: FSTL3
• Immunogen: Recombinant protein Follistatin Like Protein 3. The antigen corresponds to amino acid range 24-256 of the target protein.
• Quantity: 20 μL
• Primary or Secondary: Primary
• Target Species: Mouse
• Product Type: Antibody
• Isotype: IgG