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Tocris Bioscience™ FTIDC
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Catalog No. 500010
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10 mg
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Catalog No. Quantity
50-001-0 10 mg
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Catalog No. 50-001-0 Supplier Tocris Bioscience™ Supplier No. 5000/10
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Description

Potent and selective negative allosteric modulator at mGlu1; also mGlu1 inverse agonist

FTIDC is a potent and selective mGlu1 receptor negative allosteric modulator (IC50 values are 5.8 and 6200 nM for mGlu1 and mGlu5 respectively). Also acts as an mGlu1 receptor inverse agonist (IC50 = 7 nM) in the absence of ligand. Exhibits no effect at group II/III mGlu receptors. Inhibits L-glutamate-induced increases in intracellular calcium in mGlu1-expressing CHO cells. Inhibits nociceptive behavior, and exhibits anxiolytic and antipsychotic effects in vivo. Orally active.

Specifications

Quantity 10 mg
Product Type FTIDC
Purity >98%
Molecular Weight (g/mol) 358.41
Inhibitors FTIDC

For Research Use Only

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