Tocris Bioscience™ FTIDC 

Potent and selective negative allosteric modulator at mGlu1; also mGlu1 inverse agonist

Manufacturer:  Tocris Bioscience™ 5000/10

Catalog No. 50-001-0

Description

Potent and selective mGlu1 receptor negative allosteric modulator (IC50 values are 5.8 and 6200 nM for mGlu1 and mGlu5 respectively). Also acts as an mGlu1 receptor inverse agonist (IC50 = 7 nM) in the absence of ligand. Exhibits no effect at group II/III mGlu receptors. Inhibits L-glutamate-induced increases in intracellular calcium in mGlu1-expressing CHO cells. Inhibits nociceptive behavior, and exhibits anxiolytic and antipsychotic effects in vivo. Orally active.

This product(s) resides on a Fisher Scientific GSA or VA contract. If you are viewing this page as a nonregistered user, the price(s) displayed is List Price. To view your GSA or VA contract pricing, log in using your account number, or become a registered user by contacting one of our Customer Service teams. You can also view your contract price by searching for this item(s) on GSA Advantage. To place an order, contact Fisher Scientific Customer Service.

Specifications

• Product Type: FTIDC
• Purity: >98
• Quantity: 10mg

• Inhibitors: FTIDC
• Molecular Weight: 358.41

For Research Use Only