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  5. Tocris Bioscience™ FTY 720

Tocris Bioscience™ FTY 720
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Catalog No. 617650
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Quantity:
10 mg
50 mg
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Catalog No. 61-765-0

Supplier: Tocris Bioscience™ 6176/50

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Description

Potent S1P receptor agonist; also immunosuppressant

FTY 720 is an S1P receptor agonist; undergoes phosphorylation by sphingosine kinase 2, which then binds S1P1,3,4 and 5 receptors (EC50 values are 0.3 - 0.6 nM for S1P1, 4 and 5 and ∼3 nM for S1P3). Immunosuppressant; sequesters lymphocytes in lymph nodes, reducing autoimmune response. Suppresses the development of EAE (an in vivo model of MS). Orally bioavailable and blood-brain barrier permeable.

Specifications

CAS 162359-56-0
Quantity 50 mg
Target Sphingosine-1-phosphate Receptor
Molecular Formula C19H33NO2.HCl
Formula Weight 343.93g/mol
Product Type Agonist

For Research Use Only

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