Fucosyltransferase 3/FUT3 Antibody (SPM194), Alexa Fluor™ 750, Novus Biologicals™

Mouse Monoclonal Antibody

Supplier:  Novus Biologicals NBP247928AF750

Catalog No. NP247928A70

Description

Fucosyltransferase 3/FUT3 Monoclonal specifically detects Fucosyltransferase 3/FUT3 in Human, Guinea Pig samples. It is validated for Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Paraffin, Immunofluorescence.

Specifications

• Antigen: Fucosyltransferase 3/FUT3
• Classification: Monoclonal
• Conjugate: Alexa Fluor 750
• Formulation: 50 mM sodium borate with 0.05% sodium azide
• Host Species: Mouse
• Quantity: 0.1 mL
• Gene ID (Entrez): 2525
• Target Species: Human, Guinea Pig
• Isotype: IgG1 κ

• Applications: Immunohistochemistry, Immunohistochemistry (Paraffin), Immunofluorescence
• Clone: SPM194
• Dilution: Immunohistochemistry, Immunohistochemistry-Paraffin, Immunofluorescence
• Gene Symbols: FUT3
• Immunogen: Mucin isolated from a human ovarian cyst fluid (Uniprot: P21217)
• Primary or Secondary: Primary
• Test Specificity: The Lewis histo-blood group system comprises a set of fucosylated glycosphingolipids that are synthesized by exocrine epithelial cells and circulate in body fluids. The glycosphingolipids function in embryogenesis, tissue differentiation, tumor metastasis, inflammation, and bacterial adhesion. They are secondarily absorbed to red blood cells giving rise to their Lewis phenotype. This gene is a member of the fucosyltransferase family, which catalyzes the addition of fucose to precursor polysaccharides in the last step of Lewis antigen biosynthesis. It encodes an enzyme with alpha(1,3)-fucosyltransferase and alpha(1,4)-fucosyltransferase activities. Lewis blood group antigens are carbohydrate moieties structurally integrated in mucous secretions. Lewis antigen system alterations have been described in gastric carcinoma and associated lesions. Anomalous expression of Lewis B antigen has been found in some non-secretory gastric carcinomas and colorectal cancers.
• Content And Storage: Store at 4°C in the dark.