Fucosyltransferase 3/FUT3 Antibody (SPM194) - Azide and BSA Free, Novus Biologicals™

Mouse Monoclonal Antibody

Supplier:  Novus Biologicals NBP2479280.2MG

Catalog No. NBP247928B

Description

Blood Group Lewis b Monoclonal antibody specifically detects Antigen in Guinea Pig, Human samples. It is validated for Immunofluorescence, Immunohistochemistry (Paraffin).

Specifications

• Antigen: Blood Group Lewis b
• Classification: Monoclonal
• Concentration: 1.0 mg/mL
• Dilution: Immunohistochemistry-Paraffin : 0.5 - 1.0 ug/ml, Immunofluorescence : 0.5 - 1.0 ug/ml
• Gene Alias: alpha-(1,3/1,4)-fucosyltransferase, Blood group Lewis alpha-4-fucosyltransferase, CD174, EC 2.4.1, EC 2.4.1.65, FT3B, Fucosyltransferase 3, fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group), Fucosyltransferase III, FucT-III, galactoside 3(4)-L-fucosyltransferase, LEfucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood groupincluded), Les, Lewis FT, MGC131739
• Host Species: Mouse
• Molecular Weight of Antigen: 45 kDa
• Quantity: 0.2 mg
• Primary or Secondary: Primary
• Test Specificity: The Lewis histo-blood group system comprises a set of fucosylated glycosphingolipids that are synthesized by exocrine epithelial cells and circulate in body fluids. The glycosphingolipids function in embryogenesis, tissue differentiation, tumor metastasis, inflammation, and bacterial adhesion. They are secondarily absorbed to red blood cells giving rise to their Lewis phenotype. This gene is a member of the fucosyltransferase family, which catalyzes the addition of fucose to precursor polysaccharides in the last step of Lewis antigen biosynthesis. It encodes an enzyme with alpha(1,3)-fucosyltransferase and alpha(1,4)-fucosyltransferase activities. Lewis blood group antigens are carbohydrate moieties structurally integrated in mucous secretions. Lewis antigen system alterations have been described in gastric carcinoma and associated lesions. Anomalous expression of Lewis B antigen has been found in some non-secretory gastric carcinomas and colorectal cancers.
• Content And Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Isotype: IgG1 κ

• Applications: Immunohistochemistry (Paraffin), Immunofluorescence
• Clone: SPM194
• Conjugate: Unconjugated
• Formulation: PBS with No Preservative
• Gene Symbols: FUT3
• Immunogen: Mucin isolated from a human ovarian cyst fluid
• Purification Method: Protein A or G purified
• Regulatory Status: RUO
• Gene ID (Entrez): 2525
• Target Species: Human, Guinea Pig
• Form: Purified