Invitrogen™ Fumarase Monoclonal Antibody (GT7612)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA527746

Catalog No. PIMA527746

Description

Positive Control: 293T, A431, HeLa, HepG2, mouse liver, rat liver Predicted Reactivity: Zebrafish (90%), Pig (98%), Chicken (91%), Sheep (99%), Chimpanzee (99%), Bovine (98%) Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

The protein encoded by this gene is an enzymatic component of the tricarboxylic acid cycle, or Krebs cycle, and catalyzes the formation of L-malate from fumarate. It exists in both a cytosolic form and an N-terminal extended form, differing only in the translation start site used. The N-terminal extended form is targeted to the mitochondrion, where the removal of the extension generates the same form as in the cytoplasm. It is similar to some thermostable class II fumarases and functions as a homotetramer. Mutations in this gene can cause fumarase deficiency and lead to progressive encephalopathy.

Specifications

• Antigen: Fumarase
• Classification: Monoclonal
• Concentration: 3 mg/mL
• Formulation: PBS with no preservative
• Gene Accession No.: P07954, P14408, P97807
• Gene Symbols: FH, Fh1
• Immunogen: Recombinant protein encompassing a sequence within the center region of human Fumarate hydratase. The exact sequence is proprietary.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG3

• Applications: Western Blot, Immunocytochemistry
• Clone: GT7612
• Conjugate: Unconjugated
• Gene: FH
• Gene Alias: EF-3; Fh; Fh1; Fh-1; FMRD; fumarase; fumarate hydratase; fumarate hydratase 1; fumarate hydratase, mitochondrial; HLRCC; LRCC; MCL; MCUL1
• Host Species: Mouse
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 14193, 14194, 2271, 24368
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid