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Invitrogen™ Fumarase Polyclonal Antibody
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Catalog No. PIPA596393
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100 μL
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PIPA596393 100 μL
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Catalog No. PIPA596393 Supplier Invitrogen™ Supplier No. PA596393
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Description

Rabbit Polyclonal Antibody

Positive Samples: U-87MG, LO2, 22Rv1, NCI-H460, HL-60, NIH/3T3, Mouse heart, Mouse kidney, Rat liver; Cellular Location: Cytoplasm, Mitochondrion Immunogen sequence: ASQNSFRIEY DTFGELKVPN DKYYGAQTVR STMNFKIGGV TERMPTPVIK AFGILKRAAA EVNQDYGLDP KIANAIMKAA DEVAEGKLND HFPLVVWQTG SGTQTNMNVN EVISNRAIEM LGGELGSKIP VHPNDHVNKS QSSNDTFPTA MHIAAAIEVH EVLLPGLQKL HDALDAKSKE FAQIIKIGRT HTQDAVPLTL GQEFSGYVQQ VKYAMTRIKA AMPRIYELAA GGTAVGTGLN TRIGFAEKVA AKVAALTGLP FVTAPNKFEA LAAHDALVEL SGAMNTTACS LMKIANDIRF LGSGPRSGLG ELILPENEPG SSIMPGKVNP TQCEAMTMVA AQVMGNHVAV TVGGSNGHFE LNVFKPMMIK NVLHSARLLG DASVSFTENC VVGIQANTER INKLMNESLM LVTALNPHIG YDKAAKIAKT AHKNGSTLKE TAIELGYLTA EQFDEWVKPK DMLGPK.

The protein encoded by this gene is an enzymatic component of the tricarboxylic acid cycle, or Krebs cycle, and catalyzes the formation of L-malate from fumarate. It exists in both a cytosolic form and an N-terminal extended form, differing only in the translation start site used. The N-terminal extended form is targeted to the mitochondrion, where the removal of the extension generates the same form as in the cytoplasm. It is similar to some thermostable class II fumarases and functions as a homotetramer. Mutations in this gene can cause fumarase deficiency and lead to progressive encephalopathy.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Fumarase
Applications ELISA, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.4 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene FH
Gene Accession No. P07954, P14408, P97807
Gene Alias EF-3; Fh; Fh1; Fh-1; FMRD; fumarase; fumarate hydratase; fumarate hydratase 1; fumarate hydratase, mitochondrial; HLRCC; LRCC; MCL; MCUL1
Gene Symbols FH, Fh1
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 45-510 of human FH (NP_0001342).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 14193, 14194, 2271, 24368
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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