Invitrogen™ FUT11 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA553114

Catalog No. PIPA553114

Description

Immunogen sequence: MKYLAYKQPG GITNQFLLDS LKHREWGVND PLLPNYLNGF ECFVCDYELA RLDAEKAHAA SPGDSPVFEP HIAQPSHMDC PVPTPGFGNV EEIPENDSWK EMWLQDYWQG LDQGEALTAM IHNNETEQTK FWDYL Highest antigen sequence identity to the following orthologs: Mouse - 87%, Rat - 89%.

The FUT11 gene encodes for fructosyltransferase 11, an enzyme that is part of the glycosyltransferase family involved in the modification of glycoproteins and glycolipids by catalyzing the addition of fucose moieties. Enzymes like FUT11 play a critical role in the biosynthesis of Lewis antigen structures, significantly contributing to cell-cell adhesion, signal transduction, and immune recognition. Fucosylation, the process mediated by fructosyltransferases, is crucial for various biological functions, including the regulation of leukocyte trafficking and selectin binding, emphasizing its importance in immune responses and inflammation. While FUT11 is less characterized compared to other fucosyltransferases, altered expression patterns and functional abnormalities in these enzymes are linked to pathological conditions, such as cancer and inflammatory diseases, where changes in glycosylation can affect tumor progression, metastasis, and immune evasion. Ongoing research into FUT11 aims to elucidate its specific role in cellular processes and explore potential therapeutic applications by targeting fucosylation pathways to modify disease progression.

Specifications

• Antigen: FUT11
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: FUT11
• Gene Alias: 3110009G03Rik; AI317183; alpha (1,3) fucosyltransferase; alpha-(1,3)-fucosyltransferase 11; alpha3-fucosyltransferase 11; EC 2.4.1; Fucosyltransferase 11; fucosyltransferase 11 (alpha (1,3) fucosyltransferase); fucosyltransferase XI; fuc-TXI; fucT-XI; Fut11; Galactoside 3-L-fucosyltransferase 11; MGC119338; MGC119339; MGC33202
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 170384
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Immunocytochemistry
• Concentration: 0.2 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q495W5
• Gene Symbols: FUT11
• Immunogen: Recombinant protein corresponding to Human FUT11. Recombinant protein control fragment (Product #RP-90784).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov