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Invitrogen™ FUT8 Polyclonal Antibody
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Catalog No. PIPA5100534
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100 μL
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PIPA5100534 100 μL
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Catalog No. PIPA5100534 Supplier Invitrogen™ Supplier No. PA5100534
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total FUT8.

Alpha-(1,6)-fucosyltransferase (FUT8) is a gene located on chromosome 14q23.3, encoding an enzyme that catalyzes the addition of fucose to N-glycans via alpha-1,6-linkage. This fucosylation is important in modifying glycoproteins, influencing their function, stability, and interactions within biological systems. FUT8 activity is crucial in various physiological processes, including immune regulation, cell signaling, and development. Aberrant fucosylation patterns, due to altered FUT8 expression, have been associated with pathological conditions such as cancer and inflammatory diseases. In oncology, FUT8-mediated core fucosylation of glycoproteins is linked to tumor progression, metastasis, and therapeutic resistance, making it a potential biomarker for cancer diagnosis and prognosis. Additionally, FUT8's role in immune function highlights its involvement in cellular communication and homeostasis, offering insights into therapeutic strategies aimed at modulating glycosylation pathways to address disease states.
TRUSTED_SUSTAINABILITY

Specifications

Antigen FUT8
Applications Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene FUT8
Gene Accession No. Q6EV76, Q9BYC5, Q9WTS2
Gene Alias alpha (1,6) fucosyltransferase; alpha-(1,6)-fucosyltransferase; alpha-1,6-fucosyltransferase; alpha1-6FucT; EC 2.4.1.68; Fucosyltransferase 8; fucosyltransferase 8 (alpha (1,6) fucosyltransferase); FUT8; GDP-fucose--glycoprotein fucosyltransferase; GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase; Glycoprotein 6-alpha-L-fucosyltransferase; MGC26465
Gene Symbols FUT8
Host Species Rabbit
Immunogen A synthesized peptide derived from human FUT8(Accession Q9BYC5), corresponding to amino acid residues G275-V325.
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 2530, 432392, 53618
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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