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Invitrogen™ FUT8 Polyclonal Antibody
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Catalog No. PIPA547774
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100 μg
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PIPA547774 100 μg
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Catalog No. PIPA547774 Supplier Invitrogen™ Supplier No. PA547774
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Description

Sheep Polyclonal Antibody

In direct ELISAs, less than 1% cross-reactivity with recombinant human (rh) FUT3, rhFUT5, and rhFUT11 is observed. Reconstitute at 0.2 mg/mL in sterile PBS.

Alpha-(1,6)-fucosyltransferase (FUT8) is a gene located on chromosome 14q23.3, encoding an enzyme that catalyzes the addition of fucose to N-glycans via alpha-1,6-linkage. This fucosylation is important in modifying glycoproteins, influencing their function, stability, and interactions within biological systems. FUT8 activity is crucial in various physiological processes, including immune regulation, cell signaling, and development. Aberrant fucosylation patterns, due to altered FUT8 expression, have been associated with pathological conditions such as cancer and inflammatory diseases. In oncology, FUT8-mediated core fucosylation of glycoproteins is linked to tumor progression, metastasis, and therapeutic resistance, making it a potential biomarker for cancer diagnosis and prognosis. Additionally, FUT8's role in immune function highlights its involvement in cellular communication and homeostasis, offering insights into therapeutic strategies aimed at modulating glycosylation pathways to address disease states.
TRUSTED_SUSTAINABILITY

Specifications

Antigen FUT8
Applications Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Classification Polyclonal
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 5% trehalose and No Preservative
Gene FUT8
Gene Accession No. Q9BYC5
Gene Alias alpha (1,6) fucosyltransferase; alpha-(1,6)-fucosyltransferase; alpha-1,6-fucosyltransferase; alpha1-6FucT; EC 2.4.1.68; Fucosyltransferase 8; fucosyltransferase 8 (alpha (1,6) fucosyltransferase); FUT8; GDP-fucose--glycoprotein fucosyltransferase; GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase; Glycoprotein 6-alpha-L-fucosyltransferase; MGC26465
Gene Symbols FUT8
Host Species Sheep
Immunogen CHO-derived recombinant human Fucosyltransferase 8/FUT8 Asp32-Lys575.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 2530
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Lyophilized
Isotype IgG
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