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  6. Invitrogen™ FZD4 Monoclonal Antibody (145901)

Invitrogen™ FZD4 Monoclonal Antibody (145901)

Catalog No. PIMA524377
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PIMA524377 50 μg
PIMA523923 100 μg
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Catalog No. PIMA524377 Supplier Invitrogen™ Supplier No. MA524377
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Description

Rat Monoclonal Antibody

In Western blots, no cross-reactivity with recombinant mouse (rm) Frizzled-1, -2, -3, -6, -7, -8, or recombinant human Frizzled-5 is observed. This antibody detects Frizzled-4 by flow cytometry and immunohistochemistry on mouse differentiated embryoid bodies derived from the mouse embryonic cell line, D3. Reconstitute at 0.5 mg/mL in sterile PBS.

FZD4 is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This protein may play a role as a positive regulator of the Wingless type MMTV integration site signaling pathway. A transcript variant retaining intronic sequence and encoding a shorter isoform has been described, however, its expression is not supported by other experimental evidence. Frizzled 4 is widely expressed, particularly in heart, skeletal muscle, ovary, and fetal kidney. Transcripts have also been identified in liver, kidney, pancreas, spleen, and fetal lung, and in smaller amounts in placenta, adult lung, prostate, testis, colon, and fetal brain.
TRUSTED_SUSTAINABILITY

Specifications

Antigen FZD4
Applications Flow Cytometry, Western Blot, Immunocytochemistry
Classification Monoclonal
Clone 145901
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 5% trehalose and No Preservative
Gene FZD4
Gene Accession No. Q61088, Q9ULV1
Gene Alias CD344; CD344 antigen; EVR1; FEVR; frizzled 4, seven transmembrane spanning receptor; frizzled class receptor 4; frizzled family receptor 4; frizzled homolog 4; frizzled homolog 4 (Drosophila); frizzled receptor 4; frizzled-4; Fz4; Fz-4; Fzd4; FZD4S; FzE4; GPCR; hFz4; mFz4; MGC34390; rFz4; WNT receptor frizzled-4
Gene Symbols FZD4
Host Species Rat
Immunogen Mouse myeloma cell line NS0-derived recombinant mouse Frizzled-4 Phe37-Glu180.
Purification Method Protein A/G
Quantity 50 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 14366, 8322
Target Species Human, Mouse
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Lyophilized
Isotype IgG2a
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