Invitrogen™ FZD7 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA14137

Catalog No. PA14137

Description

PA1-4137 detects mouse frizzled. PA1-4137 has been successfully used in Western blot procedures. By Western blot this antibody detects a ~40 kDa protein representing mouse fz in mouse pancreas lysate. The PA1-4137 immunogen is a synthetic peptide corresponding to residues M(1) R G P G T A A S H S P C(12) of mouse Frizzled. This sequence is 91% conserved in rat.

Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif. FZD7 gene expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas.

Specifications

• Antigen: FZD7
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: FZD7
• Gene Alias: frizzled 7, seven transmembrane spanning receptor; frizzled class receptor 7; frizzled family receptor 7; frizzled homolog 7; frizzled homolog 7 (Drosophila); Frizzled, drosophila, homolog of, 7; frizzled-7; Fz7; Fz-7; FZD7; FzE3; hFz7; LOC100360552; mFz7; rCG22430-like; rizzled 7
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 14369
• Content And Storage: Maintain refrigerated at 2°C to 8°C for up to 3 months. For long term storage store at -20°C
• Form: Liquid

• Applications: Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 0.02% sodium azide
• Gene Accession No.: Q61090
• Gene Symbols: FZD7
• Immunogen: Synthetic peptide corresponding to residues M(1) R G P G T A A S H S P C(12) of mouse Frizzled.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Mouse
• Product Type: Antibody
• Isotype: IgG