Invitrogen™ FZD8 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5120635

Catalog No. PIPA5120635

Description

Positive test controls include: 293T, A-549, HeLa, Mouse liver, Rat liver. Immunogen sequence: PDRMRCDRLP EQGNPDTLCM DYNRTDLTTA APSPPRRLPP PPPGEQPPSG SGHGRPPGAR PPHRGGGRGG GGGDAAAPPA RGGGGGGKAR PPGGGAAPCE PGCQCRAPMV SVSSERHPLY NRVKTGQIAN CALPCHNPFF SQDERA.

Members of the Frizzled family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. Frizzled 8 is highly expressed in two human cancer cell lines, indicating that it may play a role in several types of cancer. Its expression has been reported in brain, heart, kidney, pancreas, and skeletal muscle. ESTs have been isolated from embryo, eye, head/neck, heart, kidney, liver/spleen, pancreas, prostate, and testis libraries, as well as many tumor libraries. The crystal structure of the extracellular cysteine-rich domain of a similar mouse protein has been determined.

Specifications

• Antigen: FZD8
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Fzd8
• Gene Alias: frizzled 8, seven transmembrane spanning receptor; frizzled class receptor 8; frizzled family receptor 8; frizzled homolog 8; frizzled homolog 8 (Drosophila); frizzled-8; Fz8; Fz-8; Fzd8; hFZ8; HGNC:4046
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 14370, 364754, 8325
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 0.96 mg/mL
• Formulation: PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
• Gene Accession No.: Q498S8, Q61091, Q9H461
• Gene Symbols: Fzd8
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 130-275 of human FZD8 (NP_114072.1).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG