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  5. Tocris Bioscience™ G 5555

Tocris Bioscience™ G 5555
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Catalog No. 605110
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60-511-0 10 mg
60-515-0 50 mg
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Catalog No. 60-511-0 Supplier Tocris Bioscience™ Supplier No. 6051/10
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Description

High affinity group 1 PAK inhibitor

G 5555 is a high affinity group 1 PAK (pan-PAK1, 2 and 3) inhibitor (Ki = 3.7 nM; pMEK IC50 = 69 nM). Of 235 kinases tested, other than PAK1, eight (PAK2, PAK3, KHS1, Lck, MST3, MST4, SIK2, and YSK1) were inhibited >70%. Exhibits low hERG channel activity (<50% inhibition at 10 μM). Orally bioavailable.

Specifications

Chemical Name or Material 8-[(trans-5-Amino-1,3-dioxan-2-yl)methyl]-6-[2-chloro-4-(6-methyl-2-pyridinyl)phenyl]-2-(methylamino)-pyrido[2,3-d]pyrimidin-7(8H)-one
CAS 1648863-90-4
Assay Percent Range >98%
Quantity 10 mg
Molecular Formula C25H25ClN6O3
Formula Weight Observed MW: 492.96
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