G gamma4 Rabbit anti-Human, Polyclonal, Bioss

Catalog No.	Quantity
50-198-2736	100 μL

Catalog No. 50-198-2736 Supplier Bioss Supplier No. BS13245R

Description

Rabbit Polyclonal Antibody

MYH (mutY homolog (E. coli )) is a DNA glycosylase mismatch repair enzyme that in conjunction with mutM (OGG1), cleaves adenine residues paired with either oxidized (8-hydroxyguanines) or non-modified guanines in order to correct A/G and A/C mismatches. Repair of most modified and mispaired bases in the genome is initiated by DNA glycosylases, which bind and cleave N-glycosyl bonds to initiate base excision repair. MYH is crucial for the avoidance of mutations resulting from oxidative DNA damage. Multiple N-terminal splice variants of MYH exist in mammalian cells. Increasing levels of MYH in A549 cells exposed to oxygen and infrared radiation leads to improvements in cell survival. Biallelic MYH germ-line mutations predispose humans to colorectal adenomas and carcinomas. MYH is abundant in neurons where mitochondrial genomes exposed to reactive oxygen species (ROS) that damage DNA must maintain integrity over the entire mammalian life span.

Specifications

• Antigen: G gamma4
• Applications: Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
• Classification: Polyclonal
• Concentration: 1 μg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
• Gene: MUTYH
• Gene Accession No.: Q9UIF7
• Gene Alias: 5730495A01Rik; A/G-specific adenine DNA glycosylase; Adenine DNA glycosylase; adenine-DNA glycosylase; CYP2C; hMYH; MGC4416; mMYH; mutY DNA glycosylase; MutY homolog; mutY homolog (E. coli); mutY homolog alpha; Mutyh; Mutyha; Mutyhalpha; Mutyhb; Mutyhbeta; Mutyhc; mutY-like protein; Myh; OTTHUMP00000009098; OTTHUMP00000009102; rMYH; RP4-534D1.2; the full-length form type A, 5′ region
• Gene Symbols: MUTYH
• Host Species: Rabbit
• Immunogen: KLH conjugated synthetic peptide derived from human G gamma4.
• Purification Method: Protein A
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 4595
• Target Species: Human
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG