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Invitrogen™ G0S2 Polyclonal Antibody
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Catalog No. PIPA5109748
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100 μL
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PIPA5109748 100 μL
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Catalog No. PIPA5109748 Supplier Invitrogen™ Supplier No. PA5109748
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: METVQELIPL AKEMMAQKRK GKMVKLYVLG SVLALFGVVL GLMETVCSPF TAARRLRDQE AAVAELQAAL ERQALQKQAL QEKGKQQDTV LGGRALSNRQ.

The G(0)-G(1) switch gene 2 (G0S2) codes for a mitochondrial protein that is important in apoptosis, lipolysis, and triacylglycerol hydrolysis. In adipocytes, G0S2 binds to adipose triglyceride lipase and decreases the breakdown of lipid droplets. In Crohn's colitis, the presence of G0S2 is increased in correlation to the amount of non-converted lipid in waste. In squamous lung cancer, mutations in the G0S2 gene are common. In breast cancer, epigenetic silencing of G0S2 occurs, and normal apoptotic regulation of aberrant cells is negatively impacted. However, when G0S2 is not epigenetically modified, it is the best mediator of the Bcl-2/Bax heterodimer, resulting in apoptosis of cancerous cells.
TRUSTED_SUSTAINABILITY

Specifications

Antigen G0S2
Applications ELISA, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1.15 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene G0s2
Gene Accession No. P27469, Q5M840, Q61585
Gene Alias AI255151; AV006465; G0/G1 switch 2; G0/G1 switch gene 2; G0/G1 switch protein 2; G0/G1 switch regulatory protein 2; G0/G1switch 2; G0s2; G0S2-like protein; putative lymphocyte G0/G1 switch; Putative lymphocyte G0/G1 switch gene; putative lymphocyte G0/G1 switch protein 2; RP1-28O10.2
Gene Symbols G0s2
Host Species Rabbit
Immunogen Synthetic peptide.
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 14373, 289388, 50486
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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