Invitrogen™ G0S2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA589635

Catalog No. PIPA589635

Description

Immunogen sequence: METVQELIPL AKEMMAQKRK GKMVKLYVLG SVLALFGVVL GLMETVCSPF TAARRLRDQE AAVAELQAAL ERQALQKQAL QEKGKQQDTV LGGRALSNRQ; Positive Samples: K-562, 293T; Cellular Location: Mitochondrion.

The G(0)-G(1) switch gene 2 (G0S2) codes for a mitochondrial protein that is important in apoptosis, lipolysis, and triacylglycerol hydrolysis. In adipocytes, G0S2 binds to adipose triglyceride lipase and decreases the breakdown of lipid droplets. In Crohn's colitis, the presence of G0S2 is increased in correlation to the amount of non-converted lipid in waste. In squamous lung cancer, mutations in the G0S2 gene are common. In breast cancer, epigenetic silencing of G0S2 occurs, and normal apoptotic regulation of aberrant cells is negatively impacted. However, when G0S2 is not epigenetically modified, it is the best mediator of the Bcl-2/Bax heterodimer, resulting in apoptosis of cancerous cells.

Specifications

• Antigen: G0S2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: G0s2
• Gene Alias: AI255151; AV006465; G0/G1 switch 2; G0/G1 switch gene 2; G0/G1 switch protein 2; G0/G1 switch regulatory protein 2; G0/G1switch 2; G0s2; G0S2-like protein; putative lymphocyte G0/G1 switch; Putative lymphocyte G0/G1 switch gene; putative lymphocyte G0/G1 switch protein 2; RP1-28O10.2
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 50486
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 0.48 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: P27469
• Gene Symbols: G0s2
• Immunogen: A synthetic peptide corresponding to a sequence within amino acids 1-100 of human G0S2 (NP_0565291).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG