Invitrogen™ G6B Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA587682

Catalog No. PIPA587682

Description

Immunogen sequence: NPGASLDGRP GDRVNLSCGG VSHPIRWVWA PSFPACKGLS KGRRPILWAS SSGTPTVPPL QPFVGRLRSL DSGIRRLELL LSAGDSGTFF CKGRHEDESR TVLHVLGDRT YCKAPGPTHG SVYPQ; Positive Samples: K-562, Jurkat, SW620, Mouse intestine, Mouse pancreas, Rat pancreas; Cellular Location: Cell membrane, Endoplasmic reticulum, Golgi apparatus, Golgi apparatus, Single-pass type I membrane protein.

G6B is a member of the immunoglobulin (Ig) superfamily with 241 amino acids and is a glycosylated, plasma membrane-bound cell surface receptor, but soluble isoforms encoded by some transcript variants have been found in the endoplasmic reticulum and Golgi before being secreted. Multiple transcript variants encoding different isoforms have been reported. RT-PCR, Western blot, and flow cytometric analyses suggest that G6B is usually expressed on platelets and cross linking of G6B inhibits platelet aggregation and activation in a calcium-independent manner by agonists such as ADP and collagen-related peptide. G6B is an inhibitory surface receptor on platelets and may be an antithrombotic drug target. Isoform B is a putative inhibitory receptor. Isoform A may be its activating counterpart. It is known to bind to heparin. G6B is usually expressed in a restricted set of hematopoietic cell lines like K562, Molt4 and Jurkat and not detected in the cell lines like U937, Raji, Tk, HeLa, NKL, NK62 and YT.

Specifications

• Antigen: G6B
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Mpig6b
• Gene Alias: AU023871; C6orf25; chromosome 6 open reading frame 25; DADB-110M10.2; G6b; G6B-B; immunoglobulin receptor; immunoreceptor tyrosine-based inhibitory motif (ITIM) containing platelet receptor; Immunoreceptor tyrosine-based inhibitory motif (ITIM)-containing platelet receptor; ITIM-receptor G6b-B; Megakaryocyte and platelet inhibitory receptor G6b; MPIG6B; NG31; Protein G6b
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 106722, 406865, 80739
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 2.25 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: D7PDD4, O95866, Q6MG59
• Gene Symbols: Mpig6b
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 18-142 of human C6orf25 (NP_6121211).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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