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Invitrogen™ G6B Polyclonal Antibody
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Catalog No. PIPA5140079
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100 μL
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PIPA5140079 100 μL
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Catalog No. PIPA5140079 Supplier Invitrogen™ Supplier No. PA5140079
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Description

Rabbit Polyclonal Antibody

Gently mix before use. Optimal concentrations and conditions for each application should be determined by the user. Immunogen sequence: APLVKTEPQR PVKEEEPKIP GDLDQEPSLL YADLDHLALS RPRRLSTADP ADA Highest antigen sequence indentity to the following orthologs: Mouse - 62%, Rat - 58%.

G6B is a member of the immunoglobulin (Ig) superfamily with 241 amino acids and is a glycosylated, plasma membrane-bound cell surface receptor, but soluble isoforms encoded by some transcript variants have been found in the endoplasmic reticulum and Golgi before being secreted. Multiple transcript variants encoding different isoforms have been reported. RT-PCR, Western blot, and flow cytometric analyses suggest that G6B is usually expressed on platelets and cross linking of G6B inhibits platelet aggregation and activation in a calcium-independent manner by agonists such as ADP and collagen-related peptide. G6B is an inhibitory surface receptor on platelets and may be an antithrombotic drug target. Isoform B is a putative inhibitory receptor. Isoform A may be its activating counterpart. It is known to bind to heparin. G6B is usually expressed in a restricted set of hematopoietic cell lines like K562, Molt4 and Jurkat and not detected in the cell lines like U937, Raji, Tk, HeLa, NKL, NK62 and YT.
TRUSTED_SUSTAINABILITY

Specifications

Antigen G6B
Applications Immunocytochemistry
Classification Polyclonal
Concentration 0.3 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Mpig6b
Gene Accession No. O95866
Gene Alias AU023871; C6orf25; chromosome 6 open reading frame 25; DADB-110M10.2; G6b; G6B-B; immunoglobulin receptor; immunoreceptor tyrosine-based inhibitory motif (ITIM) containing platelet receptor; Immunoreceptor tyrosine-based inhibitory motif (ITIM)-containing platelet receptor; ITIM-receptor G6b-B; Megakaryocyte and platelet inhibitory receptor G6b; MPIG6B; NG31; Protein G6b
Gene Symbols Mpig6b
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human MPIG6B. Recombinant protein control fragment (Product #RP-108912).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 80739
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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