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Tocris Bioscience™ G6PDi 1

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Quantity:
10 mg
Description
G6PDi 1 is a potent, reversible, nonsteroidal inhibitor of glucose-6-phosphate dehydrogenase (G6PD) (IC50 = 70 nM. The compound dose-dependently and reversibly decreases 6-phosphogluconolactone (6-PG) levels in HCT116 and HepG2 cell lines in vitro. In activated T cells, G6PDi-1 inhibits flux through the pentose phosphate pathway and decreases NADPH generation. It also inhibits production of cytokines by activated T cells and oxidative burst in neutrophils.
Specifications
Specifications
Chemical Name or Material | 4-((5-Oxo-6,7,8,9-tetrahydro-5H-cyclohepta[d]pyrimidin-2-yl)amino)thiophene-2-carbonitrile |
CAS | 2457232-14-1 |
Quantity | 10 mg |
Target | Glucose 6 Phosphate Dehydrogenase |
Molecular Formula | C14H12N4OS |
Purity | 0.98 |
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