Invitrogen™ GABARAP Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA14146

Catalog No. PA14146

Description

PA1-4146 detects GABA Receptor Associated Protein Subunit 2 in human and rat samples. PA1-4146 has been successfully used Western blot procedures. By Western blot this antibody detects a ~105 kDa protein representing GABA Receptor Associated Protein Subunit 2 in brain lysate. The PA1-4146 immunogen is a synthetic peptide corresponding to residues T(42) R G A P R P P P S S P P(54) of the 105 kDa rat GABA R2 protein.

Gamma-aminobutyric acid (GABA) is the main inhibitory transmitter by increasing a Cl-conductance that inhibits neuronal firing in the central nervous system. It has been shown to activate both ionotropic (GABAA) and metabotropic (GABAB) receptors as well as a third class of receptors called GABAC. GABARAP (GABAA receptor-associated protein) links GABAA receptors to the cytoskeleton and may play a role in intracellular transport of GABAA receptors and its interaction with the cytoskeleton. GABARAP belongs to the MAP1 or ATG8 like family and recent studies show that MAPK15/ERK8 is acting through interaction with ATG8 family proteins to regulate autophagy.

Specifications

• Antigen: GABARAP
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: GABARAP
• Gene Alias: ATG8A; FLC3B; FLJ25768; GABA type A receptor-associated protein; GABA(A) receptor-associated protein; GABA-A receptor-associated protein; Gabarap; GABARAP a; GABARAP-a; gamma-aminobutyric acid receptor associated protein; gamma-aminobutyric acid receptor-associated protein; gamma-aminobutyric acid reseptor associated protein; HT004; hypothetical protein; MGC120154; MGC120155; MM46
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 11337, 58974
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 0.02% sodium azide
• Gene Accession No.: O95166, P60517
• Gene Symbols: GABARAP
• Immunogen: Synthetic peptide corresponding to residues T(42) R G A P R P P P S S P P(54) of the 105 kDa rat GABA R2 protein.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Rat
• Product Type: Antibody
• Isotype: IgG