Invitrogen™ GABARAP Polyclonal Antibody

Catalog No.	Quantity
PA14147	100 μg

Catalog No. PA14147 Supplier Invitrogen™ Supplier No. PA14147

Description

Rabbit Polyclonal Antibody

PA1-4147 detects GABA Receptor Associated Protein in human, rat, mouse, bovine, and non-human primate samples. PA1-4147 has been successfully used in Western blot procedures. By Western blot this antibody detects a ~116 kDa protein representing GABA Receptor Associated Protein in brain lysate. The PA1-4147 immunogen is a synthetic peptide corresponding to residues P(33) H L P R P H P R V P P H P S S E R R A V Y(54) of the mouse and rat GABA R1 subunit.

Gamma-aminobutyric acid (GABA) is the main inhibitory transmitter by increasing a Cl-conductance that inhibits neuronal firing in the central nervous system. It has been shown to activate both ionotropic (GABAA) and metabotropic (GABAB) receptors as well as a third class of receptors called GABAC. GABARAP (GABAA receptor-associated protein) links GABAA receptors to the cytoskeleton and may play a role in intracellular transport of GABAA receptors and its interaction with the cytoskeleton. GABARAP belongs to the MAP1 or ATG8 like family and recent studies show that MAPK15/ERK8 is acting through interaction with ATG8 family proteins to regulate autophagy.

Specifications

• Antigen: GABARAP
• Applications: Western Blot
• Classification: Polyclonal
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 0.02% sodium azide
• Gene: GABARAP
• Gene Accession No.: O95166, P60517, Q9DCD6, Q9GJW7
• Gene Alias: ATG8A; FLC3B; FLJ25768; GABA type A receptor-associated protein; GABA(A) receptor-associated protein; GABA-A receptor-associated protein; Gabarap; GABARAP a; GABARAP-a; gamma-aminobutyric acid receptor associated protein; gamma-aminobutyric acid receptor-associated protein; gamma-aminobutyric acid reseptor associated protein; HT004; hypothetical protein; MGC120154; MGC120155; MM46
• Gene Symbols: GABARAP
• Host Species: Rabbit
• Immunogen: Synthetic peptide corresponding to residues P(33) H L P R P H P R V P P H P S S E R R A V Y(54) of the mouse and rat GABA R1 subunit.
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 11337, 327715, 56486, 58974
• Target Species: Human, Mouse, Rat, Monkey, Bovine
• Content And Storage: Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG