Invitrogen™ GABBR1 Monoclonal Antibody (N93A/49), FITC

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA545537

Catalog No. PIMA545537

Description

1 μg/mL of MA5-45537 was sufficient for detection of GABA(B)R1 in 20 μg of rat brain membrane lysate and assayed by colorimetric immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody. Detects approximately 115kDa. No cross-reactivity against GABA(B)R2. This antibody was formerly sold as clone S93A-49.

Receptor for GABA. The activity of this receptor is mediated by G-proteins that inhibit adenylyl cyclase activity, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipids hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA-B-R inhibit neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA-B-R decrease neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception.

Specifications

• Antigen: GABBR1
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS, 9.09mM sodium bicarbonate with 640.91mM DMSO, 136.36mM ethanolamine and no preservative; pH 7.4
• Gene Accession No.: Q9UBS5, Q9WV18, Q9Z0U4
• Gene Symbols: GABBR1
• Immunogen: Fusion protein amino acids 873-977 (cytoplasmic C-terminus) of rat GABA(B)R1.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG1

• Applications: Western Blot, Immunocytochemistry
• Clone: N93A/49
• Conjugate: FITC
• Gene: GABBR1
• Gene Alias: bM573K1.1; bM573K1.1.1 (gamma-aminobutyric acid (GABA) B receptor, 1a); DAAP-188P13.3; dJ271M21.1.1; dJ271M21.1.2; FLJ92613; GABA(B) receptor; GABAB; GABA-B receptor 1; GABA-B receptor, R1 subunit; GABAB1; Gaba-b1; GABAbR1; GABA-BR1; GABA-B-R1; Gababr1 receptor; Gaba-b-r1a; Gaba-br1a receptor; GABA-BR1b receptor; Gabbr1; GABBR1-3; gamma-aminobutyric acid; gamma-aminobutyric acid (GABA) B receptor 1; gamma-aminobutyric acid (GABA) B receptor, 1; gamma-aminobutyric acid (GABA-B) receptor, 1; gamma-aminobutyric acid type B receptor subunit 1; GB1; GBR1; GPRC3A; HGB1a; OTTHUMP00000109099; OTTHUMP00000214725; seven transmembrane helix receptor
• Host Species: Mouse
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 2550, 54393, 81657
• Content And Storage: 4°C, store in dark
• Form: Liquid

Safety and Handling

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