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Invitrogen™ GABBR1 Polyclonal Antibody
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Catalog No. PIPA517075
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100 μL
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PIPA517075 100 μL
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Catalog No. PIPA517075 Supplier Invitrogen™ Supplier No. PA517075
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Description

Rabbit Polyclonal Antibody

It is not recommended to aliquot this antibody.

Receptor for GABA. The activity of this receptor is mediated by G-proteins that inhibit adenylyl cyclase activity, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipids hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA-B-R inhibit neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA-B-R decrease neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception.
TRUSTED_SUSTAINABILITY

Specifications

Antigen GABBR1
Applications Immunoprecipitation, Western Blot
Classification Polyclonal
Concentration 48 μg/mL
Conjugate Unconjugated
Formulation 0.01M HEPES with 100 μg/mL BSA, 50% glycerol, 0.15M NaCl and no preservative; pH 7.5
Gene GABBR1
Gene Accession No. Q9UBS5, Q9WV18, Q9Z0U4
Gene Alias bM573K1.1; bM573K1.1.1 (gamma-aminobutyric acid (GABA) B receptor, 1a); DAAP-188P13.3; dJ271M21.1.1; dJ271M21.1.2; FLJ92613; GABA(B) receptor; GABAB; GABA-B receptor 1; GABA-B receptor, R1 subunit; GABAB1; Gaba-b1; GABAbR1; GABA-BR1; GABA-B-R1; Gababr1 receptor; Gaba-b-r1a; Gaba-br1a receptor; GABA-BR1b receptor; Gabbr1; GABBR1-3; gamma-aminobutyric acid; gamma-aminobutyric acid (GABA) B receptor 1; gamma-aminobutyric acid (GABA) B receptor, 1; gamma-aminobutyric acid (GABA-B) receptor, 1; gamma-aminobutyric acid type B receptor subunit 1; GB1; GBR1; GPRC3A; HGB1a; OTTHUMP00000109099; OTTHUMP00000214725; seven transmembrane helix receptor
Gene Symbols GABBR1
Host Species Rabbit
Immunogen Synthetic peptide corresponding to human GABA(B)R1.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 2550, 54393, 81657
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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