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Invitrogen™ GABBR1 Recombinant Rabbit Monoclonal Antibody (JE60-09)
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Catalog No. FEMA550825
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FEMA550825 100 μL
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Catalog No. FEMA550825 Supplier Invitrogen™ Supplier No. MA550825
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Description

Rabbit Recombinant Monoclonal Antibody

Positive control: K-562 cell lysate, Jurkat cell lysate, HeLa cell lysate, SHG-44 cell lysate, mouse brain tissue. Predicted band size: 108 kDa Subcellular Location: Cell membrane, Postsynaptic cell membrane, Cell projection, dendrite; Secreted.

Receptor for GABA. The activity of this receptor is mediated by G-proteins that inhibit adenylyl cyclase activity, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipids hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA-B-R inhibit neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA-B-R decrease neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception.
TRUSTED_SUSTAINABILITY

Specifications

Antigen GABBR1
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Recombinant Monoclonal
Clone JE60-09
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.05% BSA, 40% glycerol and 0.05% sodium azide; pH 7.4
Gene GABBR1
Gene Accession No. Q9UBS5, Q9WV18
Gene Alias bM573K1.1; bM573K1.1.1 (gamma-aminobutyric acid (GABA) B receptor, 1a); DAAP-188P13.3; dJ271M21.1.1; dJ271M21.1.2; FLJ92613; GABA(B) receptor; GABAB; GABA-B receptor 1; GABA-B receptor, R1 subunit; GABAB1; Gaba-b1; GABAbR1; GABA-BR1; GABA-B-R1; Gababr1 receptor; Gaba-b-r1a; Gaba-br1a receptor; GABA-BR1b receptor; Gabbr1; GABBR1-3; gamma-aminobutyric acid; gamma-aminobutyric acid (GABA) B receptor 1; gamma-aminobutyric acid (GABA) B receptor, 1; gamma-aminobutyric acid (GABA-B) receptor, 1; gamma-aminobutyric acid type B receptor subunit 1; GB1; GBR1; GPRC3A; HGB1a; OTTHUMP00000109099; OTTHUMP00000214725; seven transmembrane helix receptor
Gene Symbols GABBR1
Host Species Rabbit
Immunogen Recombinant protein within Human GABA B Receptor 1 aa 35-134/961.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 2550, 54393
Target Species Human, Mouse
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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