Invitrogen™ GABBR2 Monoclonal Antibody (N81/2), FITC

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA545534

Catalog No. PIMA545534

Description

1 μg/mL of MA5-45534 was sufficient for detection of GABA(B)R2 in 20 μg of rat brain membrane lysate and assayed by colorimetric immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody. Detects approximately 105kDa. No cross-reactivity against GABA(B)R1. This antibody was formerly sold as clone S81-2.

The multi-pass membrane protein, GABBR2, belongs to the G-protein coupled receptor 3 family and GABA-B receptor subfamily. The GABA-B receptors inhibit neuronal activity through G protein-coupled second-messenger systems, which regulate the release of neurotransmitters, and the activity of ion channels and adenylyl cyclase. This receptor subunit forms an active heterodimeric complex with GABA-B receptor subunit 1, neither of which is effective on its own. Allelic variants of this gene have been associated with nicotine dependence.

Specifications

• Antigen: GABBR2
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS, 9.1mM sodium bicarbonate with 640.91mM DMSO, 136.36mM ethanolamine and no preservative; pH 7.4
• Gene Accession No.: O75899, O88871, Q80T41
• Gene Symbols: GABBR2
• Immunogen: Fusion protein amino acids 861-912 of rat GABA(B)R2.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG1

• Applications: Immunohistochemistry, Western Blot, Immunocytochemistry
• Clone: N81/2
• Conjugate: FITC
• Gene: GABBR2
• Gene Alias: FLJ36928; G protein-coupled receptor 51; GABA BR; GABA-B R2 receptor; GABA-B receptor 2; GABA-B receptor, R2 subunit; GABABR2; GABA-BR2; GABA-B-R2; Gabbr2; gamma-aminobutyric acid; gamma-aminobutyric acid (GABA) B receptor 2; gamma-aminobutyric acid (GABA) B receptor, 2; gamma-aminobutyric acid B receptor 2; gamma-aminobutyric acid type B receptor subunit 2; gamma-aminobutyric acid type B receptor, subunit 2; gb2; Gm425; Gpr51; GPRC3B; G-protein coupled receptor 51; HG20; HRIHFB2099; MGC119386; MGC119388; MGC119389; ortholog of human G protein-coupled receptor 51 GPR51; RP23-337N2.1
• Host Species: Mouse
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 242425, 83633, 9568
• Content And Storage: 4°C, store in dark
• Form: Liquid

Safety and Handling

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