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GABRA1 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech
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Catalog No. 501727963 Shop All Proteintech Group Inc Products
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50-172-7963 150 μL
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Catalog No. 50-172-7963 Supplier Proteintech Group Inc Supplier No. 124101AP150UL
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Description

Rabbit Polyclonal Antibody

Gamma -aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl- channel associated with the GABAA Receptor (GABAA-R) subtype. GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and substance abuse. The GABAA-R is a multimeric subunit complex. To date aix alphas, four betas and four gammas, plus alternative splicing variants of some of these subunits, have been identified. Injection in oocytes or mammalian cell lines of cRNA coding for alpha- and beta-subunits results in the expression of functional GABAA-R sensitive to GABA. However, coexpression of a gamma-subunit is required for benzodiazepine modulation. The various effects of the benzodiazepines in brain may also be mediated via different alpha-subunits of the receptor. Lastly, phosphorylation of beta-subunits of the receptor has been shown to modulate GABAA-R function.

Specifications

Antigen GABRA1
Applications Flow Cytometry, Immunoprecipitation, Western Blot
Classification Polyclonal
Concentration 0.23 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
Gene GABRA1
Gene Accession No. P14867, P62812, P62813
Gene Alias ECA4, EJM, GABA A receptor alpha 1, GABAA receptor alpha 1, GABRA1
Gene Symbols Gabra1
Host Species Rabbit
Immunogen GABRA1 Fusion Protein Ag3117
Purification Method Antigen Affinity Chromatography
Quantity 150 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 14394, 2554, 29705
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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