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GABRA1 Rabbit anti-Human, Polyclonal, Bioss
SDP

Catalog No. 501985635
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50-198-5635 100 μL
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Catalog No. 50-198-5635 Supplier Bioss Supplier No. BS3766R
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Description

Rabbit Polyclonal Antibody

Gamma -aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl- channel associated with the GABAA Receptor (GABAA-R) subtype. GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and substance abuse. The GABAA-R is a multimeric subunit complex. To date aix alphas, four betas and four gammas, plus alternative splicing variants of some of these subunits, have been identified. Injection in oocytes or mammalian cell lines of cRNA coding for alpha- and beta-subunits results in the expression of functional GABAA-R sensitive to GABA. However, coexpression of a gamma-subunit is required for benzodiazepine modulation. The various effects of the benzodiazepines in brain may also be mediated via different alpha-subunits of the receptor. Lastly, phosphorylation of beta-subunits of the receptor has been shown to modulate GABAA-R function.

Specifications

Antigen GABRA1
Applications Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 μg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
Gene GABRA1
Gene Accession No. P14867
Gene Alias BOS_8416; ECA4; EIEE19; EJM; EJM5; GABA(A) receptor subunit alpha-1; GABA(A) receptor, alpha 1; GABAA alpha 1; GABAAR alpha1; GABRA 1; Gabra1; Gabra-1; gamma-aminobutyric acid A receptor, alpha 1; gamma-aminobutyric acid (GABA) A receptor, alpha 1; gamma-aminobutyric acid (GABA) A receptor, subunit alpha 1; gamma-aminobutyric acid (GABA) A receptor, subunit alpha 1-like; gamma-aminobutyric acid (GABA-A) receptor, subunit alpha 1; gamma-aminobutyric acid A receptor, alpha 1; Gamma-aminobutyric acid receptor subunit alpha-1; gamma-aminobutyric acid receptor subunit alpha-1-like; gamma-aminobutyric acid type A receptor alpha1 subunit; LOC100357047
Gene Symbols GABRA1
Host Species Rabbit
Immunogen KLH conjugated synthetic peptide derived from human GABRA1.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 2554
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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