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Invitrogen™ GABRA4 Monoclonal Antibody (N398A/34)
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Catalog No. PIMA527701
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100 μg
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Catalog No. Quantity
PIMA527701 100 μg
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Catalog No. PIMA527701 Supplier Invitrogen™ Supplier No. MA527701
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Description

Mouse Monoclonal Antibody

A 1:100 dilution of MA5-27701 was sufficient for detection of GABA-A R, Alpha4 in 20 μg of mouse brain lysate by ECL immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody. Detects approximately 60kDa. Does not cross-react with other GABA-A-Receptor Alpha subunits. This antibody was formerly sold as clone S398A-34.

Gamma-aminobutyric acid is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. This gene encodes subunit alpha-4, which is involved in the etiology of autism and eventually increases autism risk through interaction with another subunit, gamma-aminobutyric acid receptor beta-1. Alternatively spliced transcript variants encoding different isoforms have been found in this gene.
TRUSTED_SUSTAINABILITY

Specifications

Antigen GABRA4
Applications Immunohistochemistry (PFA fixed), Western Blot, Immunocytochemistry
Classification Monoclonal
Clone N398A/34
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.1% sodium azide; pH 7.4
Gene GABRA4
Gene Accession No. P28471, P48169, Q9D6F4
Gene Alias GABA(A) receptor; GABA(A) receptor subunit alpha-4; GABA(A) receptor, alpha 4; GABA-A receptor alpha-4 subunit; GABAARalpha4; Gabra4; Gabra-4; gamma-aminobutyric acid; gamma-aminobutyric acid (GABA) A receptor, alpha 4; gamma-aminobutyric acid (GABA) A receptor, subunit alpha 4; gamma-aminobutyric acid (GABA-A) receptor, subunit alpha 4; gamma-aminobutyric acid A receptor alpha 4; gamma-aminobutyric acid receptor subunit alpha-4; gamma-aminobutyric acid type A receptor alpha4 subunit
Gene Symbols GABRA4
Host Species Mouse
Immunogen Fusion protein amino acids 410-450 (Cytoplasmic C-terminus) of rat GABA-A-Receptor Alpha 4.
Purification Method Protein G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 140675, 14397, 2557
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG1
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