Invitrogen™ GABRA4 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5109752

Catalog No. PIPA5109752

Description

Immunogen sequence: QNQKEEKLCT ENFTRILDSL LDGYDNRLRP GFGGPVTEVK TDIYVTSFGP VSDVEMEYTM DVFFRQTWID KRLKYDGPIE ILRLNNMMVT KVWTPDTFFR NGKKSVSHNM TAPNKLFRIM RNGTILYTMR LTISAECPMR LVDFPMDGHA CPLKFGSYAY PKSEMIYTWT KGPEKSVEVP KESSSLVQYD LIGQTVSSET IKSITGEYIV MTVYFHLRRK MGY.

Gamma-aminobutyric acid is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. This gene encodes subunit alpha-4, which is involved in the etiology of autism and eventually increases autism risk through interaction with another subunit, gamma-aminobutyric acid receptor beta-1. Alternatively spliced transcript variants encoding different isoforms have been found in this gene.

Specifications

• Antigen: GABRA4
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: GABRA4
• Gene Alias: GABA(A) receptor; GABA(A) receptor subunit alpha-4; GABA(A) receptor, alpha 4; GABA-A receptor alpha-4 subunit; GABAARalpha4; Gabra4; Gabra-4; gamma-aminobutyric acid; gamma-aminobutyric acid (GABA) A receptor, alpha 4; gamma-aminobutyric acid (GABA) A receptor, subunit alpha 4; gamma-aminobutyric acid (GABA-A) receptor, subunit alpha 4; gamma-aminobutyric acid A receptor alpha 4; gamma-aminobutyric acid receptor subunit alpha-4; gamma-aminobutyric acid type A receptor alpha4 subunit
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 140675
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 1.44 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: P28471
• Gene Symbols: GABRA4
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 36-258 of human GABRA4 (NP_000800.2).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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