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Invitrogen™ GABRA6 Polyclonal Antibody
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Catalog No. PIPA536590
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PIPA536590 100 μL
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Catalog No. PIPA536590 Supplier Invitrogen™ Supplier No. PA536590
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Description

Rabbit Polyclonal Antibody

This antibody detects endogenous protein at a molecular weight of 51 kDa. Purity is >95% by SDS-PAGE.

Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl- channel associated with the GABA-A Receptor (GABA-A R) Subtype. GABA-A Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and substance abuse. The GABA-A R is a multimeric subunit complex. To date six alphas, four betas and four gammas, plus alternative splicing variants of some of these subunits, have been identified. Injection in oocytes or mammalian cell lines of cRNA coding for alpha and beta subunits results in the expression of functional GABA-A Rs sensitive to GABA. However, coexpression of a gamma-subunit is required for benzodiazepine modulation. The various effects of the benzodiazepines in brain may also be mediated via different alpha subunits of the receptor. Lastly, phosphorylation of beta subunits of the receptor has been shown to modulate GABA-A R function.
TRUSTED_SUSTAINABILITY

Specifications

Antigen GABRA6
Applications Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.05% sodium azide; pH 7.2
Gene Gabra6
Gene Accession No. P16305, P30191, Q16445
Gene Alias alpha6; GABA subunit A receptor alpha 6; GABA(A) receptor subunit alpha-6; GABA(A) receptor, alpha 6; GABA-A receptor alpha-6 subunit; GABAAR alpha6; GABA-ARalpha6; GABRA 6; Gabra6; Gabra-6; gamma-aminobutyric acid; gamma-aminobutyric acid A receptor, alpha 6; gamma-aminobutyric acid (GABA) A receptor, alpha 6; gamma-aminobutyric acid (GABA) A receptor, subunit alpha 6; gamma-aminobutyric acid (GABA-A) receptor, subunit alpha 6; gamma-aminobutyric acid A receptor, alpha 6; gamma-aminobutyric acid receptor subunit alpha-6; gamma-aminobutyric acid type A receptor alpha6 subunit; subunit alpha 6 gamma-aminobutyric acid (GABA-A) receptor
Gene Symbols Gabra6
Host Species Rabbit
Immunogen Synthetic peptide corresponding to amino acids 66-121 of human GABAA R alpha6.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 14399, 2559, 29708
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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