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Invitrogen™ GABRB2 Polyclonal Antibody
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Catalog No. PIPA5119918
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100 μL
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PIPA5119918 100 μL
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Catalog No. PIPA5119918 Supplier Invitrogen™ Supplier No. PA5119918
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Description

Rabbit Polyclonal Antibody

Positive Control: Human brian tissue lysate, rat cerebellum tissue lysate, rat brian tissue lysate, mouse brain tissue, A549. Subcellular Location: Cytoplasmic.

GAD-65 and GAD-67, glutamate decarboxylases, function to catalyze the production of GABA (gamma-aminobutyric acid). In the central nervous system GABA functions as the main inhibitory transmitter by increasing a Cl- conductance that inhibits neuronal firing. GABA has been shown to activate both ionotropic (GABAA) and metabotropic (GABAB) receptors as well as a third class of receptors called GABAC. Both GABAA and GABAC are ligand-gated ion channels, however, they are structurally and functionally distinct. Members of the GABAA receptor family include GABAA Rα1-6, GABAA R β1-3, GABAA Rγ1-3, GABAA Rδ, GABAA Rε, GABAA Rρ1 and GABAA Rρ2. The GABAB family is composed of GABAB R1α and GABAB R1β. GABA transporters have also been identified and include GABA T-1, GABA T-2 and GABA T-3 (also designated GAT-1, -2, and -3). The GABA transporters function to terminate GABA action.
TRUSTED_SUSTAINABILITY

Specifications

Antigen GABRB2
Applications Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation TBS with 50% glycerol, 0.2% BSA and 0.05% sodium azide; pH 7.4
Gene GABRB2
Gene Accession No. P47870, P63137, P63138
Gene Alias AI834970; C030002O17Rik; C030021G16Rik; GABA(A) receptor subunit beta-2; GABAARbeta2; Gabrab2; GABRB2; Gabrb-2; gamma-aminobutyric acid; gamma-aminobutyric acid (GABA) A receptor, beta 2; gamma-aminobutyric acid (GABA) A receptor, subunit beta 2; gamma-aminobutyric acid (GABA-A) receptor, subunit beta 2; gamma-aminobutyric acid A receptor beta 2; gamma-aminobutyric acid A receptor, subunit beta 2; Gamma-aminobutyric acid receptor beta 2; gamma-aminobutyric acid receptor beta-2 subunit; gamma-aminobutyric acid receptor subunit beta-2; gamma-aminobutyric acid receptor, subunit beta 2; gamma-aminobutyric acid type A receptor beta2 subunit; GARB2; MGC119386; MGC119388; MGC119389
Gene Symbols GABRB2
Host Species Rabbit
Immunogen Synthetic peptide within human GABRB2 aa 350-400 (Cytoplasmic).
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 14401, 25451, 2561
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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