Invitrogen™ GABRB3 Monoclonal Antibody (N87/25), FITC

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA545466

Catalog No. PIMA545466

Description

1 μg/mL of MA5-45466 was sufficient for detection of Beta 3 GABA receptor in 10 μg of rat brain lysate by colorimetric immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody. Detects approximately 55kDa. No cross-reactivity against GABA-A-R-Beta 2 or -Beta1.

Gamma-amino butyric acid (GAMA) is a strong inhibitor of neuron transmission and is found throughout the central nervous system. GABA is formed by the decarboxylation of glutamate, resulting in the formation of one of two distinct types; GABA-A or GABA-B.The binding of GABA to GABA-A receptors results in the increase transportation of chlorine ions into the neuron. This influx results in signal transmission repression. Studies have shown that if cell to cell signaling goes unchecked due to a lack of GABA, a system overload can resulting in blackouts, rapid body contractions, seizures and epilepsy.

Specifications

• Antigen: GABRB3
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS, 9.1mM sodium bicarbonate with 640.91mM DMSO, 136.36mM ethanolamine and no preservative; pH 7.4
• Gene Accession No.: P28472, P63079, P63080
• Gene Symbols: GABRB3
• Immunogen: Fusion protein amino acids 370-433 of mouse GABA-A-R-Beta 3.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG1

• Applications: Immunohistochemistry (PFA fixed), Western Blot, Immunocytochemistry, Microarray
• Clone: N87/25
• Conjugate: FITC
• Gene: GABRB3
• Gene Alias: A230092K12Rik; AW049585; beta3; cleft palate 1; Cp1; ECA5; GABA(A) receptor subunit beta-3; GABAA receptor beta-3 subunit; GABA-alpha receptor beta-2 subunit; GABR B3; Gabrb3; Gabrb-3; gamma-aminobutyric acid; gamma-aminobutyric acid (GABA) A receptor, beta 3; gamma-aminobutyric acid (GABA) A receptor, subunit beta 3; gamma-aminobutyric acid (GABA-A) receptor, subunit beta 3; gamma-aminobutyric acid A receptor beta 3; Gamma-aminobutyric acid receptor beta 3; gamma-aminobutyric acid receptor subunit beta-3; gamma-aminobutyric acid receptor, subunit beta 3; gamma-aminobutyric acid type A receptor beta3 subunit; gamma-aminobutyric acid type A receptor subunit beta3; LOW QUALITY PROTEIN: gamma-aminobutyric acid receptor subunit beta-3; MGC9051; testis gamma-aminobutyric acid receptor subunit beta 3
• Host Species: Mouse
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 14402, 24922, 2562
• Content And Storage: 4°C, store in dark
• Form: Liquid

Safety and Handling

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