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Invitrogen™ GABRB3 Monoclonal Antibody (N87/25), PerCP
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Catalog No. PIMA545467
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100 μg
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Catalog No. Quantity
PIMA545467 100 μg
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Catalog No. PIMA545467 Supplier Invitrogen™ Supplier No. MA545467
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Description

Mouse Monoclonal Antibody

1 μg/mL of MA5-45467 was sufficient for detection of Beta 3 GABA receptor in 10 μg of rat brain lysate by colorimetric immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody. Detects approximately 55kDa. No cross-reactivity against GABA-A-R-Beta 2 or -Beta1.

Gamma-amino butyric acid (GAMA) is a strong inhibitor of neuron transmission and is found throughout the central nervous system. GABA is formed by the decarboxylation of glutamate, resulting in the formation of one of two distinct types; GABA-A or GABA-B.The binding of GABA to GABA-A receptors results in the increase transportation of chlorine ions into the neuron. This influx results in signal transmission repression. Studies have shown that if cell to cell signaling goes unchecked due to a lack of GABA, a system overload can resulting in blackouts, rapid body contractions, seizures and epilepsy.
TRUSTED_SUSTAINABILITY

Specifications

Antigen GABRB3
Applications Immunohistochemistry (PFA fixed), Western Blot, Immunocytochemistry, Microarray
Classification Monoclonal
Clone N87/25
Concentration 1 mg/mL
Conjugate PerCP
Formulation 2.48mM MES, 95.64mM phosphate with 0.5M EDTA and no preservative; pH 7.4
Gene GABRB3
Gene Accession No. P28472, P63079, P63080
Gene Alias A230092K12Rik; AW049585; beta3; cleft palate 1; Cp1; ECA5; GABA(A) receptor subunit beta-3; GABAA receptor beta-3 subunit; GABA-alpha receptor beta-2 subunit; GABR B3; Gabrb3; Gabrb-3; gamma-aminobutyric acid; gamma-aminobutyric acid (GABA) A receptor, beta 3; gamma-aminobutyric acid (GABA) A receptor, subunit beta 3; gamma-aminobutyric acid (GABA-A) receptor, subunit beta 3; gamma-aminobutyric acid A receptor beta 3; Gamma-aminobutyric acid receptor beta 3; gamma-aminobutyric acid receptor subunit beta-3; gamma-aminobutyric acid receptor, subunit beta 3; gamma-aminobutyric acid type A receptor beta3 subunit; gamma-aminobutyric acid type A receptor subunit beta3; LOW QUALITY PROTEIN: gamma-aminobutyric acid receptor subunit beta-3; MGC9051; testis gamma-aminobutyric acid receptor subunit beta 3
Gene Symbols GABRB3
Host Species Mouse
Immunogen Fusion protein amino acids 370-433 of mouse GABA-A-R-Beta 3.
Purification Method Protein G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 14402, 24922, 2562
Target Species Human, Mouse, Rat
Content And Storage 4°C
Product Type Antibody
Form Liquid
Isotype IgG1
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