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Invitrogen™ GABRR1 Polyclonal Antibody
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Catalog No. PIPA5103849
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PIPA5103849 100 μL
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Catalog No. PIPA5103849 Supplier Invitrogen™ Supplier No. PA5103849
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total GABRR1.

GAD-65 and GAD-67, glutamate decarboxylases, function to catalyze the production of GABA (gamma-aminobutyric acid). In the central nervous system GABA functions as the main inhibitory transmitter by increasing a Cl- conductance that inhibits neuronal firing. GABA has been shown to activate both ionotropic (GABAA) and metabotropic (GABAB) receptors as well as a third class of receptors called GABAC. Both GABAA and GABAC are ligand-gated ion channels; however, they are structurally and functionally distinct. GABAC receptors (GABAC Rr) mediate rapid inhibitory neurotransmission in retina. Three human genes, r1 (GABRR1), r2 (GABRR2) and r3 (GABRR3), encode the three polypeptides that comprise this receptor. GABRR1 and GABRR2 are located close together, in a region of chromosome 6q that contains loci for inherited disorders of the eye, but GABRR3 maps to chromosome 3q11-q13.3. The r polypeptide genes, which are thought to share a common ancestor with GABA(A) receptor subunit genes, diverged at an early stage in the evolution of this gene family. The expression of GABAC Rr subunits is not restricted to the retina, but significant expression can also be detected in many other brain regions, especially in those belonging to the visual pathways.
TRUSTED_SUSTAINABILITY

Specifications

Antigen GABRR1
Applications Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene GABRR1
Gene Accession No. P24046
Gene Alias bA135P14.1 (gamma-aminobutyric acid (GABA) receptor, rho 1); GABA(A) receptor subunit rho-1; GABA(A) receptor, rho 1; GABA(C) receptor; GABA(C) rho1; GABA-C; Gabrr1; gamma-aminobutyric acid; gamma-aminobutyric acid (GABA) A receptor, rho 1; gamma-aminobutyric acid (GABA) A receptor, rho-1; gamma-aminobutyric acid (GABA) C receptor, subunit rho 1; gamma-aminobutyric acid (GABA) receptor, rho 1; gamma-aminobutyric acid (GABA-A) receptor subunit rho 1; gamma-aminobutyric acid (GABA-A) receptor, subunit rho 1; gamma-aminobutyric acid (GABA-C) receptor, subunit rho 1; gamma-aminobutyric acid A receptor, rho 1; gamma-aminobutyric acid receptor subunit rho-1; gamma-aminobutyric acid type A receptor rho1 subunit
Gene Symbols GABRR1
Host Species Rabbit
Immunogen A synthesized peptide derived from human GABRR1(Accession P24046), corresponding to amino acid residues S213-S263.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 2569
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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