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GAD1 Mouse anti-Canine, Human, Clone: OTI3H2, lyophilized, TrueMAB™

Mouse Monoclonal Antibody
Supplier: OriGene CF500328

Description
Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO
GAD-65 and GAD-67 are members of the group II decarboxylase family of proteins and are responsible for catalyzing the rate limiting step in the production of GABA ( gamma-aminobutyric acid) from L-glutamic acid. Although both GADs are found in the brain, GAD-65 localizes to synaptic vesicle membranes in nerve terminals, while GAD-67 is distributed throughout the cell. GAD-67 is responsible for the basal levels of GABA synthesis. In the case of a heightened demand for GABA in neurotransmission, GAD-65 will transiently activate to assist in GABA production. The loss of GAD-65 is detrimental and can impair GABA neurotransmission, however the loss of GAD-67 is lethal. Due to alternative splicing, two isoforms exist for GAD-67: the predomit GAD-67 form and the minor GAD-25 form.Specifications
GAD1 | |
Monoclonal | |
Unconjugated | |
GAD1 | |
CPSQ1, GAD, SCP | |
Mouse | |
Affinity Chromatography | |
RUO | |
2571, 478794 | |
-20° C, Avoid Freeze/Thaw Cycles | |
Lyophilized |
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot | |
OTI3H2 | |
PBS with 8% trehalose and no preservative; pH 7.3 | |
A0PA85, Q99259 | |
GAD1 | |
Full length human recombit protein of human GAD1 produced in HEK293T cell. | |
100 μg | |
Primary | |
Canine, Human | |
Antibody | |
IgG2a |
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