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GAD1 Mouse anti-Canine, Human, Clone: OTI3H2, lyophilized, TrueMAB™
SDP

Mouse Monoclonal Antibody

Supplier:  OriGene CF500328

Encompass_Preferred

Catalog No. 50-165-9418


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Description

Description

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

GAD-65 and GAD-67 are members of the group II decarboxylase family of proteins and are responsible for catalyzing the rate limiting step in the production of GABA ( gamma-aminobutyric acid) from L-glutamic acid. Although both GADs are found in the brain, GAD-65 localizes to synaptic vesicle membranes in nerve terminals, while GAD-67 is distributed throughout the cell. GAD-67 is responsible for the basal levels of GABA synthesis. In the case of a heightened demand for GABA in neurotransmission, GAD-65 will transiently activate to assist in GABA production. The loss of GAD-65 is detrimental and can impair GABA neurotransmission, however the loss of GAD-67 is lethal. Due to alternative splicing, two isoforms exist for GAD-67: the predomit GAD-67 form and the minor GAD-25 form.
Specifications

Specifications

GAD1
Monoclonal
Unconjugated
GAD1
CPSQ1, GAD, SCP
Mouse
Affinity Chromatography
RUO
2571, 478794
-20° C, Avoid Freeze/Thaw Cycles
Lyophilized
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
OTI3H2
PBS with 8% trehalose and no preservative; pH 7.3
A0PA85, Q99259
GAD1
Full length human recombit protein of human GAD1 produced in HEK293T cell.
100 μg
Primary
Canine, Human
Antibody
IgG2a
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