GAD1 Mouse anti-Human, Clone: OTI5D8, liquid, TrueMAB™

Mouse Monoclonal Antibody

Supplier:  OriGene TA500330

Catalog No. 50-167-1472

Description

GAD-65 and GAD-67 are members of the group II decarboxylase family of proteins and are responsible for catalyzing the rate limiting step in the production of GABA ( gamma-aminobutyric acid) from L-glutamic acid. Although both GADs are found in the brain, GAD-65 localizes to synaptic vesicle membranes in nerve terminals, while GAD-67 is distributed throughout the cell. GAD-67 is responsible for the basal levels of GABA synthesis. In the case of a heightened demand for GABA in neurotransmission, GAD-65 will transiently activate to assist in GABA production. The loss of GAD-65 is detrimental and can impair GABA neurotransmission, however the loss of GAD-67 is lethal. Due to alternative splicing, two isoforms exist for GAD-67: the predomit GAD-67 form and the minor GAD-25 form.

Specifications

• Antigen: GAD1
• Classification: Monoclonal
• Concentration: 0.5 mg/mL
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
• Gene Accession No.: Q99259
• Gene Symbols: GAD1
• Immunogen: Full-length protein expressed in 293T cell transfected with human GAD1 expression vector
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1

• Applications: Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
• Clone: OTI5D8
• Conjugate: Unconjugated
• Gene: GAD1
• Gene Alias: CPSQ1, GAD, SCP
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 2571
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid