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GAD67/GAD1 Rabbit anti-Human, Polyclonal, Bioss
SDP

Catalog No. 501982554
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50-198-2554 100 μL
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Catalog No. 50-198-2554 Supplier Bioss Supplier No. BS1302R
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Description

Rabbit Polyclonal Antibody

GAD-65 and GAD-67 are members of the group II decarboxylase family of proteins and are responsible for catalyzing the rate limiting step in the production of GABA (gamma-aminobutyric acid) from L-glutamic acid. Although both GADs are found in the brain, GAD-65 localizes to synaptic vesicle membranes in nerve terminals, while GAD-67 is distributed throughout the cell. GAD-67 is responsible for the basal levels of GABA synthesis. In the case of a heightened demand for GABA in neurotransmission, GAD-65 will transiently activate to assist in GABA production. The loss of GAD-65 is detrimental and can impair GABA neurotransmission, however the loss of GAD-67 is lethal. Due to alternative splicing, two isoforms exist for GAD-67: the predominant GAD-67 form and the minor GAD-25 form.

Specifications

Antigen GAD67/GAD1
Applications ELISA, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 μg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
Gene GAD1
Gene Accession No. Q99259
Gene Alias 67 kDa glutamic acid decarboxylase; BOS_1646; CPSQ1; EP10; FLJ45882; GAD; GAD 1; GAD 67; Gad1; Gad-1; GAD25; GAD44; GAD67; GAD-67; Glutamate decarboxylase 1; Glutamate decarboxylase 1 (brain); glutamate decarboxylase 1 (brain, 67kDa); glutamate decarboxylase 1 variant GAD67NT; glutamate decarboxylase 2; Glutamate decarboxylase 67 kDa isoform; GLUTAMATE DECARBOXYLASE, 67 KD ISOFORM (GAD-67) (67 KD GLUTAMIC ACID DECARBOXYLASE); glutamic acid decarboxylase 1; LOC100344727; OTTHUMP00000041055; SCP
Gene Symbols GAD1
Host Species Rabbit
Immunogen KLH conjugated synthetic peptide derived from human GAD67.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 2571
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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