Invitrogen™ GADD45A Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA588248

Catalog No. PIPA588248

Description

Immunogen sequence: MTLEEFSAGE QKTERMDKVG DALEEVLSKA LSQRTITVGV YEAAKLLNVD PDNVVLCLLA ADEDDDRDVA LQIHFTLIQA FCCENDINIL RVSNPGRLAE LLLLETDAGP AASEGAEQPP DLHCVLVTNP HSSQWKDPAL SQLICFCRES RYMDQWVPVI NLPER; Positive Samples: HeLa, MCF7; Cellular Location: Nucleus.

GADD45 alpha, beta and gamma are an evolutionarily conserved, homologous family of nuclear proteins that function as stress sensors for cellular physiological and environmental damage. GADD45 proteins are required for the activation of the G2/M checkpoint induced by UV radiation or alkylating agents. GADD45-induced G2/M checkpoint is regulated through inactivation of Cdc2-cyclin B1 kinase. GADD45 forms a complex with p21 and Cdc2, and may serve as core for interaction with other cell cycle regulators.

Specifications

• Antigen: GADD45A
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: GADD45A
• Gene Alias: AA545191; DDIT 1; DDIT1; DDIT-1; DNA damage-inducible transcript 1 protein; DNA damage-inducible transcript-1; DNA-damage inducible transcript 1; DNA-damage-inducible transcript 1; GADD45; GADD45A; Gadd45alpha; growth arrest and DNA damage inducible alpha; growth arrest and DNA damage-inducible protein GADD45 alpha; growth arrest and DNA-damage-inducible 45 alpha; growth arrest and DNA-damage-inducible protein GADD45 alpha; growth arrest and DNA-damage-inducible, alpha
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 13197, 1647, 25112
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 0.19 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: P24522, P48316, P48317
• Gene Symbols: GADD45A
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-165 of human GADD45A (NP_0019151).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG